Leukoplakia of the Bladder (Vesical Leukoplakia) PPT

Leukoplakia of the Bladder (Vesical Leukoplakia)

  Leukoplakia is a clinical term indicating "white plaque."
  And also, leukoplakia is the clinical manifestation of histologically described keratinizing squamous metaplasia.

  Leukoplakia is known to occur in the mucous membranes of the body, including those of the urinary tract, rectum, vagina, uterus, vulva, paranasal sinuses, gallbladder, esophagus, eardrums, and pharynx.

  Currently, the clinical term "leukoplakia" is thought to be synonymous with the histopathologic diagnosis of keratinizing squamous metaplasia.

  It is distinctly different from estrogen-associated squamous metaplasia of the female trigone. (Nonkeratinizing squamous metaplasia)

  Metaplastic changes of the urothelium are associated with chronic inflammation, diverticuli, or stones and should not be confused with squamatization of the trigone (nonkeratinizing glycogenated squamous epithelium), which is a common occurrence in women during estrogen production.

  Hormone-associated squamatization of the trigone demonstrates no keratinization, intercellular bridges, or cellular atypia and is considered a normal anatomic variant.

- Similar to squamous metaplasia with the addition of keratin deposition that appears as a white flaky substance floating in the bladder (Staack et al, 2006).

 - Leukoplakia occurs in other organs that are covered by squamous epithelium and is often premalignant
  However, cytogenetic studies on bladder leukoplakia are consistent with a benign lesion, and no treatment is necessary (Staack et al, 2006).

 

Referrence 

1. Campbell Urology
   Chapter 80 : Urothelial Tumors of the Bladder

2. Staack A, Schlechte H, Sachs M, et al. Clinical value of vesical leukoplakia and evaluation of the neoplastic risk by mutation analyses of the tumor suppressor gene TP53. Int J Urol 2006;13(8):1092–7.

PPT : Vesical Leukoplakia.ppt